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Imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1 decrease the parasite burden in mice with acute toxoplasmosis

Furthermore, the efficiency of ATP production in mitochondria depends on maintaining the proton gradient across the inner mitochondrial membrane

During this treatment, a specialist will infuse vitamins, minerals, and other nutrients directly into the bloodstream

Abbreviations AsA: Ascorbate APX: Ascorbate peroxidase BCAT-like1: Branched chain aminotransferase proteins like 1 BLASTP: Protein Basic Local Alignment Search Tool CDNB: 1chlopro2,4dinitrobenzene DEGs: Differently expressed genes DEMs: Differently expressed metabolites DHAR: Dehydroascorbate reductase DRTS: Bifunctional dihydrofolate reductase-thymidylate EC: Enzyme Nomenclature folC: Dihydrofolate synthase G6PD: Glucose 6-phosphate dehydrogenase GMPS: Nucleotide guanosine 5-monophosphate synthase GO: Gene Ontology GPX: Glutathione peroxidase GR: Glutathione reductase GSH: Glutathione GSSG: Oxidized glutathione GST: Glutathione S-transferase KEGG: Kyoto Encyclopedia of Genes and Genomes LED: Light-emitting diode NCBI: National Center for Biotechnology Information NADP+: Dependent isocitrate dehydrogenase NADPH: Nicotinamide ademine dinucleotidephosphate ROS: Reactive oxygen species Spe: Spermidine SpeE: Spermidine synthase UV-C: Ultraviolet-C References Chasseaud L